Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0541 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0035 | 0 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0035 | 0 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0541 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0035 | 0 | 0.5 |
Mycobacterium leprae | Isocitrate lyase | 0.0254 | 0.432 | 0.432 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | pol-related | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0541 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0541 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0035 | 0 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0541 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 96.6 uM | Cytotoxicity against CEM/0 cells | ChEMBL. | 17485204 |
EC50 (functional) | > 10 uM | Inhibition of HIV2-induced cytopathogenicity in CEM/0 cells | ChEMBL. | 17485204 |
EC50 (functional) | > 50 uM | Inhibition of HIV1-induced cytopathogenicity in CEM/0 cells | ChEMBL. | 17485204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.