Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hedgehog | 0.0181 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 1.4 L/hr.Kg | Clearance in rat at 5 mg/kg, iv | ChEMBL. | 17513108 |
F (ADMET) | = 30 % | Oral bioavailability in rat at 15 mg/kg, po | ChEMBL. | 17513108 |
IC20 (binding) | = 0.1 uM | Inhibition of human ERG | ChEMBL. | 17513108 |
IC20 (binding) | = 0.1 uM | Inhibition of human ERG | ChEMBL. | 17513108 |
IC50 (functional) | = 0.001 uM | Antiviral activity against VZV in human foreskin fibroblast assessed as inhibition of virus plaque formation | ChEMBL. | 17513108 |
IC50 (functional) | = 0.002 uM | Antiviral activity against HCMV in human foreskin fibroblast assessed as inhibition of virus plaque formation | ChEMBL. | 17513108 |
IC50 (binding) | = 0.0058 uM | Inhibition of VZV DNA polymerase | ChEMBL. | 17513108 |
IC50 (binding) | = 0.023 uM | Inhibition of HSV1 DNA polymerase | ChEMBL. | 17513108 |
IC50 (binding) | = 0.026 uM | Inhibition of human cytomegalovirus DNA polymerase | ChEMBL. | 17513108 |
IC50 (functional) | = 1.2 uM | Antiviral activity against HSV1 in human foreskin fibroblast assessed as inhibition of virus plaque formation | ChEMBL. | 17513108 |
IC50 (binding) | > 20 uM | Inhibition of human DNA polymerase alpha | ChEMBL. | 17513108 |
Solubility | = 0.3 ug ml-1 | Solubility in aqueous solution | ChEMBL. | 17513108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.