Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.156 | 1 | 1 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0406 | 0.1098 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0406 | 0.1098 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0406 | 0.1098 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.156 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0406 | 0.1098 | 0.1098 |
Echinococcus granulosus | acetylcholinesterase | 0.156 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.156 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.156 | 1 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0406 | 0.1098 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0406 | 0.1098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.156 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0338 | 0.0574 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0406 | 0.1098 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0406 | 0.1098 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0406 | 0.1098 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0406 | 0.1098 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0406 | 0.1098 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.156 | 1 | 1 |
Brugia malayi | initiation factor 2-associated protein. | 0.0406 | 0.1098 | 0.1098 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0406 | 0.1098 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.156 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.156 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.156 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0406 | 0.1098 | 0.1098 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0406 | 0.1098 | 0.5 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0406 | 0.1098 | 0.1098 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0406 | 0.1098 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0406 | 0.1098 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.156 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0406 | 0.1098 | 0.1098 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0511 | 0.1909 | 0.1909 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0406 | 0.1098 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.156 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0338 | 0.0574 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | 0 | Intrinsic clearance in human liver microsomes | ChEMBL. | 17600707 |
CL (ADMET) | 0 | Intrinsic clearance in rat liver microsomes | ChEMBL. | 17600707 |
IC50 (binding) | Inhibition of 11beta-HSD1 in human adipocytes | ChEMBL. | 17600707 | |
IC50 (binding) | 0 | Inhibition of 11beta-HSD1 in human adipocytes | ChEMBL. | 17600707 |
Ki (binding) | = 4 nM | Binding affinity to human 11beta-HSD1 by SPA assay | ChEMBL. | 17600707 |
Ki (binding) | = 4 nM | Binding affinity to human 11beta-HSD1 by SPA assay | ChEMBL. | 17600707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.