Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | oxidoreductase GMC-type | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | FAD binding domain-containing protein | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0225 | 0.5186 | 0.5186 |
Wolbachia endosymbiont of Brugia malayi | 2-polyprenyl-6-methoxyphenol 4-hydroxylase | 0.0049 | 0 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0389 | 1 | 1 |
Plasmodium falciparum | FAD-dependent monooxygenase, putative | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0225 | 0.5186 | 0.5186 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0315 | 0.7828 | 0.7828 |
Plasmodium vivax | hypothetical protein, conserved | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0389 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0389 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0049 | 0 | 0.5 |
Toxoplasma gondii | FAD binding domain-containing protein | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0389 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0389 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0 | 0.5 |
Chlamydia trachomatis | monooxygenase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0389 | 1 | 1 |
Mycobacterium ulcerans | membrane-associated oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0315 | 0.7828 | 0.7828 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0389 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0303 | 0.7479 | 0.7479 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0389 | 1 | 1 |
Mycobacterium ulcerans | FAD-dependent oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | FAD-linked oxidoreductase | 0.0049 | 0 | 0.5 |
Mycobacterium leprae | possibleputative FAD-linked oxidoreductase | 0.0049 | 0 | 0.5 |
Plasmodium vivax | FAD-dependent monooxygenase, putative | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0389 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 52.68 uM | Cytotoxicity against human Hep2 cells | ChEMBL. | 17616396 |
EC50 (functional) | = 0.008 uM | Antiviral activity against RSV Long in Hep2 cells | ChEMBL. | 17616396 |
EC50 (functional) | > 0.5 uM | Antiviral activity against RSV Long with F1 protein K349R mutation in Hep2 cells | ChEMBL. | 17616396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.