Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldo keto reductase | 0.0449 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0449 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0449 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0449 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0449 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0449 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0449 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0319 | 0.5922 | 0.5922 |
Onchocerca volvulus | 0.0449 | 1 | 1 | |
Schistosoma mansoni | aldo-keto reductase | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0319 | 0.5922 | 0.5922 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0449 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0449 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0449 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0449 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0301 | 0.5363 | 0.5363 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.013 | 0 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0449 | 1 | 1 |
Onchocerca volvulus | 0.0449 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0449 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0309 | 0.5604 | 0.5604 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0449 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.013 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0449 | 1 | 1 |
Onchocerca volvulus | 0.0449 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0449 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0449 | 1 | 1 |
Onchocerca volvulus | 0.0449 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0449 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.013 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0449 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0449 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0449 | 1 | 1 |
Onchocerca volvulus | 0.0449 | 1 | 1 | |
Onchocerca volvulus | 0.0449 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase | 0.0449 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0449 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0449 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0449 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.013 | 0 | 0.5 |
Echinococcus granulosus | aldehyde reductase | 0.0319 | 0.5922 | 0.5922 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0449 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 28 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 2.5 uM | ChEMBL. | 17884493 |
Efficacy (functional) | = 28 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 2.5 uM | ChEMBL. | 17884493 |
Efficacy (functional) | = 32 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 25 uM | ChEMBL. | 17884493 |
Efficacy (functional) | = 32 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 25 uM | ChEMBL. | 17884493 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.