Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | carbonic anhydrase | 0.0111 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0205 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0111 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0205 | 1 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0204 | 0.9927 | 0.9927 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0205 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0205 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0205 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0205 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0205 | 1 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.0204 | 0.9927 | 0.9927 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7103 | 0.7103 |
Echinococcus granulosus | carbonic anhydrase II | 0.0205 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0205 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0205 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Cytotoxicity against human SW620 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 0 % | Cytotoxicity against human HT29 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 0 % | Cytotoxicity against human SW620 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 0 % | Cytotoxicity against human HT29 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 9 % | Cytotoxicity against human DU145 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 9 % | Cytotoxicity against human DU145 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 20 % | Cytotoxicity against human 502713 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 62 % | Cytotoxicity against human MCF7 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Inhibition (functional) | = 62 % | Cytotoxicity against human MCF7 cells at 10 uM after 48 hrs | ChEMBL. | 17950603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.