Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Kinesin motor domain containing protein | 0.0087 | 0 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0087 | 0 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0087 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0087 | 0 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0582 | 0.8507 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0087 | 0 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0087 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0669 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (binding) | = 2.36 nM | Antagonist activity at cloned human mu opioid receptor expressed in CHO cells assessed as inhibition of agonist-stimulated GTPgammaS binding | ChEMBL. | 17980586 |
Kb (binding) | = 2.36 nM | Antagonist activity at cloned human mu opioid receptor expressed in CHO cells assessed as inhibition of agonist-stimulated GTPgammaS binding | ChEMBL. | 17980586 |
Kb (functional) | = 5.49 nM | Antagonist activity at cloned human kappa opioid receptor expressed in CHO cells assessed as inhibition of agonist-stimulated GTPgammaS binding | ChEMBL. | 17980586 |
Kb (functional) | = 5.49 nM | Antagonist activity at cloned human kappa opioid receptor expressed in CHO cells assessed as inhibition of agonist-stimulated GTPgammaS binding | ChEMBL. | 17980586 |
Kb (functional) | = 48.24 nM | Antagonist activity at cloned human delta opioid receptor expressed in CHO cells assessed as inhibition of agonist-stimulated GTPgammaS binding | ChEMBL. | 17980586 |
Kb (functional) | = 48.24 nM | Antagonist activity at cloned human delta opioid receptor expressed in CHO cells assessed as inhibition of agonist-stimulated GTPgammaS binding | ChEMBL. | 17980586 |
Ki (binding) | = 11.14 nM | Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cells | ChEMBL. | 17980586 |
Ki (binding) | = 11.14 nM | Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cells | ChEMBL. | 17980586 |
Ki (binding) | = 78.09 nM | Displacement of [3H]diprenorphine from cloned human kappa opioid receptor expressed in CHO cells | ChEMBL. | 17980586 |
Ki (binding) | = 78.09 nM | Displacement of [3H]diprenorphine from cloned human kappa opioid receptor expressed in CHO cells | ChEMBL. | 17980586 |
Ki (binding) | = 232.46 nM | Displacement of [3H]bremazocine from cloned human delta opioid receptor expressed in CHO cells | ChEMBL. | 17980586 |
Ki (binding) | = 232.46 nM | Displacement of [3H]bremazocine from cloned human delta opioid receptor expressed in CHO cells | ChEMBL. | 17980586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.