Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cdc2-related kinase 1 | 0.3993 | 0.2228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 1.6904 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3993 | 0.2228 | 0.2228 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3993 | 0.2228 | 0.2228 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 1.6904 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.3993 | 0.2228 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.3993 | 0.2228 | 0.4745 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.3993 | 0.2228 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.3993 | 0.2228 | 0.2228 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.2011 | 0.1035 | 0.2204 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.3993 | 0.2228 | 0.2228 |
Brugia malayi | hypothetical protein | 0.8092 | 0.4696 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.3993 | 0.2228 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.3993 | 0.2228 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3993 | 0.2228 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.3993 | 0.2228 | 0.2228 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.3993 | 0.2228 | 0.2228 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3993 | 0.2228 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.3993 | 0.2228 | 0.2228 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.3993 | 0.2228 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.3993 | 0.2228 | 0.2228 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.2011 | 0.1035 | 0.1035 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.3993 | 0.2228 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.3993 | 0.2228 | 1 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 1.6904 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.8092 | 0.4696 | 0.4696 |
Loa Loa (eye worm) | hypothetical protein | 0.8092 | 0.4696 | 0.4696 |
Brugia malayi | cell division control protein 2 homolog | 0.3993 | 0.2228 | 0.4745 |
Giardia lamblia | Kinase, CMGC CDK | 0.3993 | 0.2228 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.3993 | 0.2228 | 0.2228 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.3993 | 0.2228 | 0.2228 |
Plasmodium vivax | protein kinase Crk2 | 0.3993 | 0.2228 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.3993 | 0.2228 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.3993 | 0.2228 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.3993 | 0.2228 | 0.2228 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.3993 | 0.2228 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.3993 | 0.2228 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.3993 | 0.2228 | 1 |
Onchocerca volvulus | 0.0292 | 0 | 0.5 | |
Echinococcus multilocularis | cyclin dependent kinase | 0.3993 | 0.2228 | 0.2228 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.3993 | 0.2228 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.3951 | 0.2203 | 0.2203 |
Plasmodium falciparum | protein kinase 5 | 0.3993 | 0.2228 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.8 | Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cells | ChEMBL. | 17604625 |
Ki (binding) | = -7.5 | Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cells | ChEMBL. | 17604625 |
Log Ki (binding) | = 7.5 | Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cells | ChEMBL. | 17604625 |
Log Ki (binding) | = 8.8 | Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cells | ChEMBL. | 17604625 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.