Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0494 | 0.7746 | 0.793 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0605 | 0.9606 | 0.983 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0615 | 0.9768 | 0.9763 |
Trypanosoma brucei | histone deacetylase 4 | 0.0615 | 0.9768 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0615 | 0.9768 | 0.9763 |
Brugia malayi | Histone deacetylase family protein | 0.0615 | 0.9768 | 1 |
Leishmania major | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0299 | 0.4482 | 0.4588 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0605 | 0.9606 | 0.983 |
Plasmodium vivax | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0605 | 0.9606 | 0.983 |
Trypanosoma brucei | histone deacetylase 3 | 0.0615 | 0.9768 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0605 | 0.9606 | 0.9597 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.0219 | 0.0224 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0605 | 0.9606 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0615 | 0.9768 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0299 | 0.4482 | 0.4359 |
Echinococcus multilocularis | histone deacetylase | 0.0615 | 0.9768 | 0.9763 |
Trypanosoma brucei | histone deacetylase 1 | 0.0605 | 0.9606 | 0.983 |
Leishmania major | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Leishmania major | histone deacetylase, putative | 0.0605 | 0.9606 | 0.9833 |
Echinococcus granulosus | histone deacetylase 7 | 0.0615 | 0.9768 | 0.9763 |
Trypanosoma brucei | histone deacetylase 2 | 0.0299 | 0.4482 | 0.4465 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0299 | 0.4482 | 0.4588 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0615 | 0.9768 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0615 | 0.9768 | 0.9763 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.0219 | 0.0224 |
Echinococcus granulosus | histone deacetylase 8 | 0.0299 | 0.4482 | 0.4359 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0605 | 0.9606 | 0.983 |
Schistosoma mansoni | histone deacetylase | 0.0605 | 0.9606 | 0.9597 |
Trypanosoma brucei | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0494 | 0.7746 | 0.7882 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0628 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0605 | 0.9606 | 0.9833 |
Echinococcus granulosus | geminin | 0.0166 | 0.2266 | 0.2093 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.2747 | 0.2648 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0309 | 0.4654 | 0.4535 |
Echinococcus granulosus | histone deacetylase 6 | 0.0615 | 0.9768 | 0.9763 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0299 | 0.4482 | 0.4359 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2266 | 0.2093 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0605 | 0.9606 | 0.9196 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0299 | 0.4482 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0615 | 0.9768 | 0.9763 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0615 | 0.9768 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0605 | 0.9606 | 0.9597 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0605 | 0.9606 | 0.9597 |
Schistosoma mansoni | histone deacetylase | 0.0605 | 0.9606 | 0.9597 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.5001 | 0.5008 |
Entamoeba histolytica | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0605 | 0.9606 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0605 | 0.9606 | 0.9833 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0615 | 0.9768 | 0.9763 |
Echinococcus granulosus | histone deacetylase | 0.0615 | 0.9768 | 0.9763 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0628 | 1 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.4482 | 0.4465 |
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 0.9606 | 0.983 |
Echinococcus granulosus | histone deacetylase 3 | 0.0605 | 0.9606 | 0.9597 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0605 | 0.9606 | 0.9833 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0605 | 0.9606 | 0.9833 |
Loa Loa (eye worm) | histone deacetylase | 0.0615 | 0.9768 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0605 | 0.9606 | 0.983 |
Brugia malayi | Histone deacetylase family protein | 0.0615 | 0.9768 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0299 | 0.4482 | 0.4359 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0605 | 0.9606 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.2266 | 0.2093 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0615 | 0.9768 | 0.9763 |
Giardia lamblia | Histone deacetylase | 0.0605 | 0.9606 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0605 | 0.9606 | 0.9833 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2266 | 0.2093 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0615 | 0.9768 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0615 | 0.9768 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0494 | 0.7746 | 0.7882 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0605 | 0.9606 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0299 | 0.4482 | 0.4588 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.477 | 0.4766 |
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0309 | 0.4654 | 0.4535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | 0 % | Activity to induce the elevation of triglycerides of male Wistar rats; No Data | ChEMBL. | 3612689 |
Control (functional) | 0 % | Activity to induce the elevation of phospholipids of male Wistar rats; No Data | ChEMBL. | 3612689 |
Control (functional) | 0 % | Activity to induce the elevation of alpha/beta cholesterol ratio of male Wistar rats; No Data | ChEMBL. | 3612689 |
Control (functional) | 0 % | Activity to induce the elevation of HDL(High Density Lipoproteins)-Cholesterol of male Wistar rats; No Data | ChEMBL. | 3612689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.