Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NAD(P)H dehydrogenase, quinone 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | Get druggable targets OG5_138113 | All targets in OG5_138113 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | Get druggable targets OG5_138113 | All targets in OG5_138113 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0276 | 0.2242 | 0.2242 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0692 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0276 | 0.2242 | 0.2242 |
Echinococcus granulosus | caspase | 0.0302 | 0.2728 | 0.2728 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0584 | 0.7979 | 1 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0692 | 1 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0312 | 0.2916 | 0.278 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.2916 | 0.278 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0584 | 0.7979 | 1 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0302 | 0.2728 | 0.2589 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0692 | 1 | 0.5 |
Schistosoma mansoni | serine-type protease inhibitor | 0.043 | 0.5117 | 0.5023 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.042 | 0.4922 | 0.4825 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0165 | 0.0188 | 0.0188 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0302 | 0.2728 | 0.2589 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0692 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0168 | 0.0241 | 0.0194 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0302 | 0.2728 | 0.2728 |
Loa Loa (eye worm) | matrixin family protein | 0.0183 | 0.0523 | 0.0342 |
Echinococcus granulosus | caspase 2 | 0.0312 | 0.2916 | 0.2916 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0692 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0168 | 0.0241 | 0.0054 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0302 | 0.2728 | 0.2728 |
Echinococcus multilocularis | caspase 2 | 0.0312 | 0.2916 | 0.2916 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0312 | 0.2916 | 1 |
Brugia malayi | Matrixin family protein | 0.0183 | 0.0523 | 0.0342 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0692 | 1 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0312 | 0.2916 | 0.278 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0692 | 1 | 1 |
Schistosoma mansoni | serine-type protease inhibitor | 0.043 | 0.5117 | 0.5023 |
Onchocerca volvulus | Matrilysin homolog | 0.0168 | 0.0241 | 0.0194 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0584 | 0.7979 | 0.5 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0692 | 1 | 0.5 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0584 | 0.7979 | 0.5 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0584 | 0.7979 | 0.5 |
Echinococcus multilocularis | caspase | 0.0302 | 0.2728 | 0.2728 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0165 | 0.0188 | 0.0188 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0692 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0692 | 1 | 1 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0692 | 1 | 0.5 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0692 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Growth inhibition of human MIA PaCa2 cells | ChEMBL. | 17999461 |
Activity (functional) | = 2.5 nmol/min | Effect on respiration rate in human MIA PaCa2 cells assessed as oxygen consumption per 10^6 cells at 100 uM | ChEMBL. | 17999461 |
Activity (functional) | = 2.5 nmol/min | Effect on respiration rate in human MIA PaCa2 cells assessed as oxygen consumption per 10^6 cells at 100 uM | ChEMBL. | 17999461 |
IC50 (binding) | = 0.25 uM | Inhibition of human recombinant NQO1 | ChEMBL. | 17999461 |
IC50 (binding) | = 0.25 uM | Inhibition of human recombinant NQO1 | ChEMBL. | 17999461 |
IC50 (binding) | = 0.6 uM | Inhibition of human recombinant NQO1 in presence of BSA | ChEMBL. | 17999461 |
IC50 (binding) | = 0.6 uM | Inhibition of human recombinant NQO1 in presence of BSA | ChEMBL. | 17999461 |
IC50 (functional) | = 140 uM | Cytotoxicity against human MIA PaCa2 cells by MTT assay | ChEMBL. | 17999461 |
IC50 (functional) | = 140 uM | Cytotoxicity against human MIA PaCa2 cells by MTT assay | ChEMBL. | 17999461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.