Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8507 | 1 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 16.8 % | Induction of monoastral spindles in HeLa cells at 100 uM after 7 hrs | ChEMBL. | 17587586 |
Activity (functional) | = 16.8 % | Induction of monoastral spindles in HeLa cells at 100 uM after 7 hrs | ChEMBL. | 17587586 |
Activity (functional) | < 25 % | Induction of monoastral spindles in HeLa cells at 50 uM after 7 hrs | ChEMBL. | 17587586 |
Activity (functional) | < 25 % | Induction of monoastral spindles in HeLa cells at 50 uM after 7 hrs | ChEMBL. | 17587586 |
IC50 (functional) | 0 | Induction of monoastral spindles in HeLa cells after 7 hrs | ChEMBL. | 17587586 |
IC50 (functional) | = 23 uM | Inhibition of Eg5 ATPase activity expressed in Escherichia coli after 12 hrs | ChEMBL. | 17587586 |
IC50 (functional) | = 23 uM | Inhibition of Eg5 ATPase activity expressed in Escherichia coli after 12 hrs | ChEMBL. | 17587586 |
IC50 (functional) | = 62.5 uM | Inhibition of microtubule-stimulated Eg5 ATPase activity expressed in Escherichia coli after 12 hrs | ChEMBL. | 17587586 |
IC50 (functional) | = 62.5 uM | Inhibition of microtubule-stimulated Eg5 ATPase activity expressed in Escherichia coli after 12 hrs | ChEMBL. | 17587586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.