Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 uM | Growth inhibition against Trypanosoma brucei brucei | ChEMBL. | 17618122 |
IC50 (functional) | = 4 uM | Growth inhibition against Trypanosoma brucei brucei | ChEMBL. | 17618122 |
IC50 (functional) | = 12 uM | Growth inhibition against Leishmania donovani | ChEMBL. | 17618122 |
IC50 (functional) | = 12 uM | Growth inhibition against Leishmania donovani | ChEMBL. | 17618122 |
IC50 (ADMET) | = 27 uM | Toxicity against monkey Vero cells | ChEMBL. | 17618122 |
IC50 (binding) | > 50 uM | Inhibition of porcine tubulin assembly | ChEMBL. | 17618122 |
IC50 (binding) | > 50 uM | Inhibition of porcine tubulin assembly | ChEMBL. | 17618122 |
IC50 (binding) | > 100 uM | Inhibition of Leishmania tarentolae tubulin assembly | ChEMBL. | 17618122 |
Inhibition (binding) | = 50 % | Inhibition of porcine tubulin assembly at 100 uM | ChEMBL. | 17618122 |
Inhibition (binding) | = 50 % | Inhibition of porcine tubulin assembly at 100 uM | ChEMBL. | 17618122 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 17618122 | ||
Leishmania donovani | ChEMBL23 | 17618122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.