Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Arachidonate 15-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Arachidonate 15-lipoxygenase | 663 aa | 676 aa | 23.2 % |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Arachidonate 15-lipoxygenase | 663 aa | 676 aa | 22.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0137 | 0.057 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0416 | 0.2817 | 0.2817 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0416 | 0.2817 | 1 |
Echinococcus granulosus | cathepsin b | 0.0416 | 0.2817 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.2817 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0416 | 0.2817 | 0.2817 |
Giardia lamblia | Cathepsin B precursor | 0.0137 | 0.057 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0416 | 0.2817 | 0.2817 |
Echinococcus granulosus | cathepsin b | 0.0416 | 0.2817 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0137 | 0.057 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0137 | 0.057 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0416 | 0.2817 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0416 | 0.2817 | 0.2817 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0137 | 0.057 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0416 | 0.2817 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0416 | 0.2817 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0137 | 0.057 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0137 | 0.057 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0137 | 0.057 | 0.057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.92 uM | Inhibition of rabbit 15-lipoxygenase in presence of linoleic acid | ChEMBL. | 17656086 |
IC50 (binding) | = 1.92 uM | Inhibition of rabbit 15-lipoxygenase in presence of linoleic acid | ChEMBL. | 17656086 |
IC50 (binding) | > 10 uM | Inhibition of rabbit 15-lipoxygenase in presence of arachidonic acid | ChEMBL. | 17656086 |
IC50 (binding) | > 10 uM | Inhibition of rabbit 15-lipoxygenase in presence of arachidonic acid | ChEMBL. | 17656086 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.