Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Serotonin N-acetyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0437 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0437 | 0.5 | 0.5 | |
Giardia lamblia | Kinase, CDC7 | 0.0437 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0437 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0437 | 0.5 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0437 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0437 | 0.5 | 0.5 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0437 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0437 | 0.5 | 0.5 | |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0437 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of PCAF HAT at 50 uM | ChEMBL. | 17924613 | |
Activity (ADMET) | 0 | Toxicity in rat pinealocytes | ChEMBL. | 17924613 |
Activity (binding) | 0 | Inhibition of PCAF HAT at 50 uM | ChEMBL. | 17924613 |
IC50 (binding) | = 11.1 uM | Inhibition of ovine AANAT by TLC-based radioactive assay | ChEMBL. | 17924613 |
IC50 (binding) | = 11.1 uM | Inhibition of ovine AANAT by TLC-based radioactive assay | ChEMBL. | 17924613 |
IC50 (binding) | = 45.2 uM | Inhibition of ovine AANAT by spectrophotometric assay | ChEMBL. | 17924613 |
IC50 (binding) | = 45.2 uM | Inhibition of ovine AANAT by spectrophotometric assay | ChEMBL. | 17924613 |
IC50 (functional) | = 100 uM | Inhibition of melatonin biosynthesis in rat pinealocytes | ChEMBL. | 17924613 |
Inhibition (binding) | = 66 % | Inhibition of ovine AANAT at 100 uM in presence of Triton X-100 by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 66 % | Inhibition of ovine AANAT at 100 uM in presence of Triton X-100 by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 74 % | Inhibition of ovine AANAT at 100 uM by alphaKD-coupled spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 74 % | Inhibition of ovine AANAT at 100 uM by alphaKD-coupled spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 81 % | Inhibition of ovine AANAT at 100 uM by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 81 % | Inhibition of ovine AANAT at 100 uM by spectrophotometric assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 98 % | Inhibition of ovine AANAT at 100 uM by TLC-based radioactive assay | ChEMBL. | 17924613 |
Inhibition (binding) | = 98 % | Inhibition of ovine AANAT at 100 uM by TLC-based radioactive assay | ChEMBL. | 17924613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.