Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrix metalloproteinase | 0.0218 | 0.1779 | 0.2445 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0265 | 0.2252 | 0.3095 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0266 | 0.2267 | 0.3115 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0563 | 0.5311 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0074 | 0.0296 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0265 | 0.2252 | 0.2252 |
Schistosoma mansoni | carbonic anhydrase | 0.0265 | 0.2252 | 0.424 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.018 | 0.139 | 0.555 |
Leishmania major | carbonic anhydrase-like protein | 0.0563 | 0.5311 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0265 | 0.2252 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.018 | 0.139 | 0.2617 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.018 | 0.139 | 0.139 |
Echinococcus multilocularis | carbonic anhydrase | 0.0265 | 0.2252 | 0.2252 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1021 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0266 | 0.2267 | 0.4579 |
Mycobacterium tuberculosis | Possible exported protein | 0.0503 | 0.4693 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0563 | 0.5311 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0265 | 0.2252 | 0.2252 |
Loa Loa (eye worm) | matrixin family protein | 0.0755 | 0.7276 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0563 | 0.5311 | 1 |
Brugia malayi | hypothetical protein | 0.0297 | 0.2588 | 0.3558 |
Echinococcus granulosus | geminin | 0.0173 | 0.1312 | 0.1312 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.2267 | 0.3115 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1779 | 0.2445 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.018 | 0.139 | 0.139 |
Echinococcus multilocularis | carbonic anhydrase | 0.0265 | 0.2252 | 0.2252 |
Brugia malayi | Matrixin family protein | 0.0218 | 0.1779 | 0.2445 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.018 | 0.139 | 0.2617 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0074 | 0.0296 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.018 | 0.139 | 0.2181 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0265 | 0.2252 | 0.424 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0173 | 0.1309 | 0.2465 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0485 | 0.4503 | 0.5396 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0265 | 0.2252 | 0.424 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0563 | 0.5311 | 0.7299 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0563 | 0.5311 | 0.7299 |
Onchocerca volvulus | 0.0297 | 0.2588 | 0.1603 | |
Brugia malayi | Inositol-1 | 0.0074 | 0.0296 | 0.0407 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.018 | 0.139 | 0.262 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0074 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.4104 | 0.5641 |
Echinococcus granulosus | carbonic anhydrase | 0.0265 | 0.2252 | 0.2252 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0074 | 0.0296 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0074 | 0.0296 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0265 | 0.2252 | 0.3095 |
Schistosoma mansoni | inositol monophosphatase | 0.0074 | 0.0296 | 0.0558 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0074 | 0.0296 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0266 | 0.2267 | 1 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.2714 | 0.511 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.018 | 0.139 | 0.555 |
Echinococcus granulosus | carbonic anhydrase II | 0.0563 | 0.5311 | 0.5311 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0563 | 0.5311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1779 | 0.2445 |
Schistosoma mansoni | inositol monophosphatase | 0.0074 | 0.0296 | 0.0558 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.018 | 0.139 | 0.5591 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0265 | 0.2252 | 0.3095 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0265 | 0.2252 | 0.3095 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0563 | 0.5311 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0074 | 0.0296 | 0.0296 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0445 | 0.4104 | 0.7727 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1312 | 0.2471 |
Brugia malayi | Matrixin family protein | 0.0218 | 0.1779 | 0.2445 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0563 | 0.5311 | 0.7299 |
Schistosoma mansoni | hypothetical protein | 0.0265 | 0.2252 | 0.424 |
Onchocerca volvulus | Matrilysin homolog | 0.0712 | 0.6828 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0265 | 0.2252 | 0.2252 |
Brugia malayi | Matrixin family protein | 0.0755 | 0.7276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.2588 | 0.3558 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2252 | 0.3095 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2252 | 0.3095 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0266 | 0.2267 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0074 | 0.0296 | 0.0407 |
Brugia malayi | Hemopexin family protein | 0.031 | 0.2714 | 0.373 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0265 | 0.2252 | 0.424 |
Brugia malayi | Matrixin family protein | 0.0218 | 0.1779 | 0.2445 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0563 | 0.5311 | 0.5311 |
Onchocerca volvulus | 0.031 | 0.2714 | 0.1851 | |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1312 | 0.2471 |
Toxoplasma gondii | hypothetical protein | 0.0265 | 0.2252 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.018 | 0.139 | 0.555 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0265 | 0.2252 | 0.3095 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1312 | 0.1312 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2252 | 0.3095 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0563 | 0.5311 | 0.7299 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0265 | 0.2252 | 0.3095 |
Loa Loa (eye worm) | matrixin family protein | 0.0485 | 0.4503 | 0.619 |
Brugia malayi | Matrixin family protein | 0.0218 | 0.1779 | 0.2445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.