Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0511 | 0.6516 | 1 |
Brugia malayi | Matrixin family protein | 0.0511 | 0.6516 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0185 | 0.0371 | 0.057 |
Mycobacterium ulcerans | hydrolase | 0.0185 | 0.0371 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0352 | 0.3513 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0352 | 0.3513 | 1 |
Mycobacterium tuberculosis | Possible exported protein | 0.0506 | 0.6427 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0352 | 0.3513 | 0.5 |
Echinococcus granulosus | geminin | 0.0167 | 0.0036 | 0.0036 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0696 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0352 | 0.3513 | 0.3513 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0352 | 0.3513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.2461 | 0.3777 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0352 | 0.3513 | 0.5391 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0036 | 0.0102 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0352 | 0.3513 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0036 | 0.0036 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.0943 | 0.2685 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0352 | 0.3513 | 0.3513 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0352 | 0.3513 | 0.5391 |
Loa Loa (eye worm) | matrixin family protein | 0.0337 | 0.3231 | 0.4959 |
Plasmodium falciparum | carbonic anhydrase | 0.0165 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0481 | 0.5945 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0296 | 0.2461 | 0.7005 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0371 | 0.057 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0352 | 0.3513 | 0.5391 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0352 | 0.3513 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0185 | 0.0371 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0337 | 0.3231 | 0.4575 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0352 | 0.3513 | 0.5391 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0036 | 0.0102 |
Toxoplasma gondii | hypothetical protein | 0.0165 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0215 | 0.0943 | 0.1447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.