Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | kinesin family 1 | 0.085 | 1 | 1 |
Plasmodium falciparum | kinesin-5 | 0.011 | 0.112 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0 | 0.0002 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Onchocerca volvulus | 0.0165 | 0.1771 | 0.5 | |
Schistosoma mansoni | kinesin eg-5 | 0.011 | 0.112 | 0.1291 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1771 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0446 | 0.2518 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0239 | 0.0276 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0 | 0.0002 |
Entamoeba histolytica | kinesin, putative | 0.011 | 0.112 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0446 | 0.2518 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0446 | 0.2518 |
Plasmodium vivax | kinesin-5 | 0.011 | 0.112 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.011 | 0.112 | 0.6323 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.011 | 0.112 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0239 | 0.1353 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0446 | 0.2518 |
Giardia lamblia | Kinesin-5 | 0.011 | 0.112 | 0.5 |
Brugia malayi | hypothetical protein | 0.0165 | 0.1771 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0739 | 0.8674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0239 | 0.1353 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.011 | 0.112 | 0.6323 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 72.73 % | Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Activity (functional) | = 72.73 % | Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Inhibition (functional) | = 27.27 % | Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Inhibition (functional) | = 27.27 % | Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.