Activity (binding)
|
|
Inhibition of topoisomerase 1
|
ChEMBL.
|
17582773
|
Activity (binding)
|
|
Inhibition of topoisomerase 1 upto 50 uM
|
ChEMBL.
|
17582773
|
Activity (binding)
|
0
|
Binding affinity to DNA assesed as melting temperature
|
ChEMBL.
|
17582773
|
Activity (binding)
|
0
|
Inhibition of topoisomerase 1
|
ChEMBL.
|
17582773
|
Activity (binding)
|
0
|
Inhibition of topoisomerase 1 upto 50 uM
|
ChEMBL.
|
17582773
|
IC50 (binding)
|
= 0.089 uM
|
Inhibition of human Chk1
|
ChEMBL.
|
17582773
|
IC50 (binding)
|
= 0.089 uM
|
Inhibition of human Chk1
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 14.7 uM
|
Antiproliferative activity against mouse L1210 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 14.7 uM
|
Antiproliferative activity against mouse L1210 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 27.4 uM
|
Antiproliferative activity against human DU145 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 27.4 uM
|
Antiproliferative activity against human DU145 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 28.9 uM
|
Antiproliferative activity against human A549 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 28.9 uM
|
Antiproliferative activity against human A549 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 30.4 uM
|
Antiproliferative activity against human HT29 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
IC50 (functional)
|
= 30.4 uM
|
Antiproliferative activity against human HT29 cells after 4 hrs by microculture tetrazolium assay
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 6 %
|
Inhibition of Chk1 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 6 %
|
Inhibition of Chk1 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 22.1 %
|
Inhibition of Src tyrosine kinase at 1 uM after 20 mins
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 22.1 %
|
Inhibition of Src tyrosine kinase at 1 uM after 20 mins
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 29 %
|
Inhibition of AMPK at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 29 %
|
Inhibition of AMPK at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 32 %
|
Inhibition of FGFR3 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 39 %
|
Inhibition of GSK3 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 40 %
|
Inhibition of CAMK2 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 51 %
|
Inhibition of P70S6K at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 51 %
|
Inhibition of P70S6K at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 69 %
|
Inhibition of CDK2/cyclin A at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 69 %
|
Inhibition of CDK2/cyclin A at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 75 %
|
Inhibition of MAPKAPK2 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 75 %
|
Inhibition of PKCalpha at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 75 %
|
Inhibition of MAPKAPK2 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 75 %
|
Inhibition of PKCalpha at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 79 %
|
Inhibition of PKCbeta at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 79 %
|
Inhibition of PKCbeta at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 86 %
|
Inhibition of PKCepsilon at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 86 %
|
Inhibition of PKCepsilon at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 92 %
|
Inhibition of LCK at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 92 %
|
Inhibition of LCK at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 94 %
|
Inhibition of CK1 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 95.4 %
|
Inhibition of human Chk1 at 10 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 95.4 %
|
Inhibition of human Chk1 at 10 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 98 %
|
Inhibition of MAPK1 at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 98 %
|
Inhibition of PKA at 1 uM
|
ChEMBL.
|
17582773
|
Inhibition (binding)
|
= 98 %
|
Inhibition of MAPK1 at 1 uM
|
ChEMBL.
|
17582773
|