Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.007 | 0 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0154 | 1 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0154 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0154 | 1 | 0.5 |
Onchocerca volvulus | 0.007 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0154 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0145 | 0.8907 | 0.8869 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0145 | 0.8907 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0154 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0154 | 1 | 0.5 |
Onchocerca volvulus | 0.007 | 0 | 0.5 | |
Trypanosoma brucei | GMP reductase | 0.0154 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.007 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0154 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0081 | 0.1261 | 0.0954 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0154 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.007 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.007 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.007 | 0 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0154 | 1 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0145 | 0.8907 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0154 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0154 | 1 | 1 |
Onchocerca volvulus | 0.007 | 0 | 0.5 | |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0154 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0154 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0154 | 1 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0154 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.007 | 0 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0154 | 1 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0154 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC95 (functional) | = 62 ug ml-1 | Antimycobacterial activity against Mycobacterium smegmatis mc2155 after 48 hrs by microdilution resazurin assay | ChEMBL. | 17208445 |
MIC95 (functional) | = 62 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by microdilution resazurin assay | ChEMBL. | 17208445 |
MIC95 (functional) | = 62 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by microdilution resazurin assay | ChEMBL. | 17208445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.