Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | beta-hexosaminidase B | 0.0356 | 1 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0087 | 0.2 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0232 | 0.6302 | 0.6254 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0087 | 0.2 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0223 | 0.6026 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0083 | 0.1869 | 0.1764 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0356 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0057 | 0.1104 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0223 | 0.6026 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0057 | 0.1104 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0083 | 0.1869 | 0.1764 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0087 | 0.2 | 1 |
Onchocerca volvulus | Hexosaminidase D homolog | 0.0083 | 0.1869 | 0.1987 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1869 | 0.1764 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1869 | 0.1764 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0356 | 1 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0087 | 0.2 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0223 | 0.6026 | 0.5975 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0087 | 0.2 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0223 | 0.6026 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0057 | 0.1104 | 0.5 |
Mycobacterium ulcerans | DNA polymerase I | 0.0057 | 0.1104 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0057 | 0.1104 | 0.5 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0356 | 1 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0087 | 0.2 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0223 | 0.6026 | 0.5975 |
Treponema pallidum | DNA polymerase I (polA) | 0.0057 | 0.1104 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0356 | 1 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0087 | 0.2 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0356 | 1 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0356 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0223 | 0.6026 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0356 | 1 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0356 | 1 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0087 | 0.2 | 1 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0319 | 0.8891 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Inhibition of the production of Interleukin-1beta from human peripheral blood monocytes stimulated with lipopolysaccharide (LPS) at 10 microM | ChEMBL. | 8496911 |
Inhibition (functional) | = 0 % | Inhibition of the production of Interleukin-1beta from human peripheral blood monocytes stimulated with lipopolysaccharide (LPS) at 10 microM | ChEMBL. | 8496911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.