Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0066 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.0233 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.0233 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0022 | 0.5 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0535 | 0.2688 | 0.2688 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0066 | 0.2081 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0022 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0022 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.0233 | 0.0211 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0048 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0095 | 0.3947 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0022 | 0.0715 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.0233 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.0233 | 0.0211 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0048 | 0.1858 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.0233 | 0.0211 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0095 | 0.3947 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.0233 | 0.0571 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0022 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0776 | 0.3981 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0022 | 0.0041 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.0066 | 0.2081 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0022 | 0.0715 |
Echinococcus multilocularis | thymidine phosphorylase | 0.1897 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0022 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0095 | 0.3947 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0095 | 0.3947 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0048 | 0.1858 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.1897 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0022 | 0.0041 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0022 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.1897 | 1 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0535 | 0.2688 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0776 | 0.3981 | 0.3967 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0776 | 0.3981 | 0.3967 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.0233 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0048 | 0.1231 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0022 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.0233 | 0.0571 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0535 | 0.2688 | 0.2672 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.0233 | 0.0211 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Reductive inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | = 38 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | = 38 uM | Inhibition of 15-hLO1 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 12-hLO | ChEMBL. | 17869117 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO2 | ChEMBL. | 17869117 |
Ratio IC50 (binding) | < 0.38 | Selectivity for 12h-LO over 15-hLO | ChEMBL. | 17869117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.