Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.2526 | 0.8119 |
Echinococcus granulosus | kinesin family 1 | 0.0658 | 0.2917 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.07 | 0.3112 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.003 | 0.0152 |
Brugia malayi | hypothetical protein | 0.0451 | 0.1972 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0168 | 0.0677 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0191 | 0.0655 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0168 | 0.0677 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0182 | 0.0742 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.1972 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0057 | 0.0167 | 0.0573 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0182 | 0.0742 | 0.007 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0168 | 0.0677 | 0.3433 |
Schistosoma mansoni | kinesin eg-5 | 0.0085 | 0.0299 | 0.0961 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0191 | 0.0614 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0191 | 0.0655 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0182 | 0.0742 | 0.007 |
Schistosoma mansoni | phosphoglucomutase | 0.0168 | 0.0677 | 0.2176 |
Entamoeba histolytica | kinesin, putative | 0.0085 | 0.0299 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.063 | 0.2791 | 0.897 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0191 | 0.0614 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0191 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0168 | 0.0677 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0191 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0168 | 0.0677 | 0.2321 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0168 | 0.0677 | 0.5 |
Brugia malayi | RNase H family protein | 0.0168 | 0.0677 | 0.3433 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0056 | 0.0165 | 0.0567 |
Plasmodium falciparum | kinesin-5 | 0.0085 | 0.0299 | 1 |
Plasmodium vivax | kinesin-5 | 0.0085 | 0.0299 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0658 | 0.2917 | 1 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.07 | 0.3112 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0085 | 0.0299 | 0.2222 |
Toxoplasma gondii | ribonuclease HI protein | 0.0168 | 0.0677 | 1 |
Schistosoma mansoni | lozenge | 0.0057 | 0.0167 | 0.0537 |
Leishmania major | ribonuclease H1, putative | 0.0168 | 0.0677 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0191 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0168 | 0.0677 | 1 |
Echinococcus multilocularis | ribonuclease H1 | 0.0168 | 0.0677 | 0.2321 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0191 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0168 | 0.0677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.1972 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0056 | 0.0165 | 0.0567 |
Schistosoma mansoni | phosphoglucomutase | 0.0168 | 0.0677 | 0.2176 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0182 | 0.0742 | 0.007 |
Onchocerca volvulus | 0.0451 | 0.1972 | 1 | |
Brugia malayi | RNase H family protein | 0.0168 | 0.0677 | 0.3433 |
Schistosoma mansoni | phosphoglucomutase | 0.0168 | 0.0677 | 0.2176 |
Brugia malayi | RNase H family protein | 0.0168 | 0.0677 | 0.3433 |
Schistosoma mansoni | lipoxygenase | 0.0056 | 0.0165 | 0.0531 |
Loa Loa (eye worm) | runx1 | 0.0057 | 0.0167 | 0.0847 |
Brugia malayi | Kinesin motor domain containing protein | 0.0085 | 0.0299 | 0.1516 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.003 | 0.0152 |
Trypanosoma brucei | unspecified product | 0.0182 | 0.0742 | 0.007 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0085 | 0.0299 | 0.1516 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 19.86 % | Hypotensive activity in anaesthetized cat assessed as blood pressure fall at 2 umol/kg, iv | ChEMBL. | 17234413 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.