Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0006 | 0.0006 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0097 | 0.0166 | 0.0166 |
Echinococcus granulosus | caspase 2 | 0.0026 | 0.0034 | 0.0034 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0026 | 0.0034 | 0.0039 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0026 | 0.0034 | 0.0266 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0707 | 0.1287 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0034 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Echinococcus multilocularis | kinesin family 1 | 0.5441 | 1 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0026 | 0.0034 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0006 | 0.0006 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0056 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0047 | 0.0362 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0056 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0034 | 0.0266 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0034 | 0.6678 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0034 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0097 | 0.0166 | 0.019 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0056 | 0.0056 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0006 | 0.0006 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0062 | 0.0071 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0026 | 0.0034 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0034 | 0.6678 |
Brugia malayi | Cell death protein 3 precursor | 0.0026 | 0.0034 | 0.0266 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0034 | 0.6678 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0097 | 0.0166 | 0.019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0034 | 0.6678 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0006 | 0.0006 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0051 | 1 |
Echinococcus granulosus | caspase | 0.0097 | 0.0166 | 0.0166 |
Entamoeba histolytica | kinesin, putative | 0.0707 | 0.1287 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0097 | 0.0166 | 0.0166 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0034 | 0.5 |
Echinococcus multilocularis | caspase | 0.0097 | 0.0166 | 0.0166 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0026 | 0.0034 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.4734 | 0.8699 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0026 | 0.0034 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0707 | 0.1287 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0707 | 0.1287 | 0.148 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0006 | 0.0007 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0026 | 0.0034 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0006 | 0.005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0034 | 0.6678 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0056 | 0.0056 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Brugia malayi | Kinesin motor domain containing protein | 0.0707 | 0.1287 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Plasmodium vivax | kinesin-5 | 0.0707 | 0.1287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0034 | 0.0266 |
Trypanosoma brucei | metacaspase 5, putative | 0.0026 | 0.0034 | 0.5 |
Echinococcus granulosus | caspase 8 | 0.0026 | 0.0034 | 0.0034 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0026 | 0.0034 | 0.6678 |
Giardia lamblia | Kinesin-5 | 0.0707 | 0.1287 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0026 | 0.0034 | 0.6678 |
Echinococcus multilocularis | caspase 3 | 0.0071 | 0.0118 | 0.0118 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0062 | 0.0071 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0006 | 0.005 |
Echinococcus multilocularis | caspase 8 | 0.0026 | 0.0034 | 0.0034 |
Trypanosoma cruzi | metacaspase, putative | 0.0026 | 0.0034 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0026 | 0.0034 | 0.0034 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0026 | 0.0034 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0006 | 0.0007 |
Trypanosoma brucei | metacaspase | 0.0026 | 0.0034 | 0.5 |
Leishmania major | metacaspase, putative | 0.0026 | 0.0034 | 0.5 |
Echinococcus granulosus | caspase 3 | 0.0071 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0707 | 0.1287 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0051 | 1 |
Trypanosoma brucei | metacaspase MCA3 | 0.0026 | 0.0034 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.