Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1123 nM | Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 mins | ChEMBL. | 17088058 |
IC50 (binding) | = 1123 nM | Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 mins | ChEMBL. | 17088058 |
IC50 (functional) | = 1400 nM | Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytes | ChEMBL. | 17088058 |
IC50 (functional) | = 1400 nM | Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytes | ChEMBL. | 17088058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.