Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0738 | 0.0995 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0209 | 0.4 | 0.5392 |
Schistosoma mansoni | glycogen phosphorylase | 0.009 | 0.1228 | 0.1858 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.0738 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0738 | 0.1117 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.0738 | 0.0738 |
Giardia lamblia | Glycogen phosphorylase | 0.0209 | 0.4 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0738 | 0.0421 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.6607 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.009 | 0.1228 | 0.3069 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0331 | 0.0501 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.0526 | 0.0526 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.0526 | 0.0708 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0209 | 0.4 | 0.5392 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.0526 | 0.0708 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0209 | 0.4 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0209 | 0.4 | 1 |
Schistosoma mansoni | lozenge | 0.0058 | 0.0481 | 0.0728 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.009 | 0.1228 | 0.3069 |
Echinococcus granulosus | glycogen phosphorylase | 0.0209 | 0.4 | 0.5392 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0055 | 0.0074 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0209 | 0.4 | 0.3795 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0209 | 0.4 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.0431 | 0.0103 |
Echinococcus granulosus | tumor protein p63 | 0.0355 | 0.7419 | 1 |
Loa Loa (eye worm) | runx1 | 0.0058 | 0.0481 | 0.0155 |
Echinococcus multilocularis | tumor protein p63 | 0.0355 | 0.7419 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0209 | 0.4 | 0.3795 |
Schistosoma mansoni | glycogen phosphorylase | 0.0209 | 0.4 | 0.6055 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0209 | 0.4 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.009 | 0.1228 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0058 | 0.0481 | 0.0649 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.0526 | 0.0795 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0738 | 0.0995 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.0738 | 0.1845 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0209 | 0.4 | 0.5392 |
Schistosoma mansoni | glycogen phosphorylase | 0.0209 | 0.4 | 0.6055 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0738 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.009 | 0.1228 | 0.3069 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.009 | 0.1228 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0209 | 0.4 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0055 | 0.0074 |
Echinococcus granulosus | glycogen phosphorylase | 0.0209 | 0.4 | 0.5392 |
Trypanosoma brucei | RNA helicase, putative | 0.032 | 0.6607 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0209 | 0.4 | 0.4 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0738 | 0.5 |
Onchocerca volvulus | 0.0465 | 1 | 1 | |
Echinococcus multilocularis | glycogen phosphorylase | 0.0209 | 0.4 | 0.5392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Uterotrophic effect (functional) | = 29.5 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 1 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 39.1 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 5 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 40.2 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 125 ug dose | ChEMBL. | 6492074 |
Uterotrophic effect (functional) | = 42.4 | Uterotrophic activity in mice as uterus dry weight(mg)/body weight (g) *100 at 25 ug dose | ChEMBL. | 6492074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.