Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-X-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 1 | 0.0441 | 0.4065 | 0.3792 |
Brugia malayi | Hexokinase family protein | 0.0441 | 0.4065 | 0.4065 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0681 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0681 | 1 | 1 |
Onchocerca volvulus | 0.0441 | 0.4065 | 0.4065 | |
Schistosoma mansoni | hexokinase | 0.0441 | 0.4065 | 0.3792 |
Entamoeba histolytica | hexokinase 2 | 0.0441 | 0.4065 | 0.3792 |
Onchocerca volvulus | 0.0441 | 0.4065 | 0.4065 | |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0681 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0441 | 0.4065 | 0.4065 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0681 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0441 | 0.4065 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0441 | 0.4065 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0441 | 0.4065 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0294 | 0.0439 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.0597 | 0.0597 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0681 | 1 | 1 |
Onchocerca volvulus | 0.0441 | 0.4065 | 0.4065 | |
Brugia malayi | hexokinase | 0.0441 | 0.4065 | 0.4065 |
Plasmodium falciparum | hexokinase | 0.0441 | 0.4065 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0441 | 0.4065 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0441 | 0.4065 | 0.4065 |
Toxoplasma gondii | hexokinase | 0.0441 | 0.4065 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0441 | 0.4065 | 0.4065 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0681 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0681 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0441 | 0.4065 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0441 | 0.4065 | 0.5 |
Leishmania major | hexokinase, putative | 0.0441 | 0.4065 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0681 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0441 | 0.4065 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0681 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0294 | 0.0439 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0441 | 0.4065 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0681 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0681 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0681 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0681 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0681 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0681 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0681 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9 nM | Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA | ChEMBL. | 17459706 |
Ki (binding) | = 9 nM | Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPA | ChEMBL. | 17459706 |
Ki (binding) | = 14 nM | Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPA | ChEMBL. | 17459706 |
Ki (binding) | = 14 nM | Displacement of [125I]IL8 from human CXCR1 expressed in CHO cells by SPA | ChEMBL. | 17459706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.