Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0217 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibition of MK2 (unknown origin) | ChEMBL. | 18221871 |
IC50 (binding) | = 10 nM | Inhibition of MK2 (unknown origin) | ChEMBL. | 18221871 |
IC50 (functional) | > 5000 nM | Inhibition of LPS-induced TNFalpha production in human THP1 cells | ChEMBL. | 18221871 |
IC50 (functional) | > 5000 nM | Inhibition of LPS-induced TNFalpha production in human THP1 cells | ChEMBL. | 18221871 |
IC50 (binding) | = 0.01 uM | Inhibition of MK2 after 30 mins by DELFIA | ChEMBL. | 17576063 |
IC50 (binding) | = 0.01 uM | Inhibition of MK2 after 30 mins by DELFIA | ChEMBL. | 17576063 |
IC50 (functional) | > 5 uM | Inhibition of LPS-stimulated TNFalpha production in THP1 cells | ChEMBL. | 17576063 |
IC50 (functional) | > 5 uM | Inhibition of LPS-stimulated TNFalpha production in THP1 cells | ChEMBL. | 17576063 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17576063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.