Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0049 | 0.5271 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0044 | 0.4416 | 0.8342 |
Trypanosoma brucei | squalene synthase, putative | 0.0077 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0049 | 0.5271 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0019 | 0.011 | 0.5 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0024 | 0.0879 | 0.2538 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0039 | 0.3463 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0879 | 0.0778 |
Brugia malayi | glutathione reductase | 0.0019 | 0.011 | 0.0317 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0044 | 0.4416 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0879 | 0.1177 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0044 | 0.4416 | 0.8342 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0039 | 0.3463 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0019 | 0.011 | 0.0317 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0039 | 0.3463 | 0.3391 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0879 | 0.2538 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0039 | 0.3463 | 0.3391 |
Trypanosoma cruzi | squalene synthase, putative | 0.0077 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0044 | 0.4416 | 0.8342 |
Giardia lamblia | Kinase, PLK | 0.0039 | 0.3463 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0049 | 0.5271 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0039 | 0.3463 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0077 | 1 | 1 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0024 | 0.0879 | 0.2538 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0039 | 0.3463 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0039 | 0.3463 | 1 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0024 | 0.0879 | 0.5 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0024 | 0.0879 | 0.149 |
Mycobacterium tuberculosis | Probable reductase | 0.0044 | 0.4416 | 0.8342 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0039 | 0.3463 | 0.3391 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0039 | 0.3463 | 0.3391 |
Schistosoma mansoni | kinase | 0.002 | 0.0161 | 0.0216 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0019 | 0.011 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0049 | 0.5271 | 1 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0024 | 0.0879 | 0.0778 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0044 | 0.4416 | 0.8342 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0019 | 0.011 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0039 | 0.3463 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0019 | 0.011 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0019 | 0.011 | 0.0317 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0019 | 0.011 | 0.0317 |
Brugia malayi | Thioredoxin reductase | 0.0019 | 0.011 | 0.0317 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.3463 | 0.4637 |
Plasmodium vivax | glutathione reductase, putative | 0.0019 | 0.011 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.3463 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0019 | 0.011 | 0.0317 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of TNFalpha-induced necroptosis in FADD-deficient Jurkat T cells | ChEMBL. | 17270434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.