Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen-related receptor beta | Starlite/ChEMBL | References |
Homo sapiens | estrogen-related receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | estrogen-related receptor alpha | 423 aa | 358 aa | 29.9 % |
Loa Loa (eye worm) | hypothetical protein | estrogen-related receptor beta | 508 aa | 461 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160 nM | Inhibition of human ERalpha | ChEMBL. | 17482813 |
IC50 (binding) | = 160 nM | Inhibition of human ERalpha | ChEMBL. | 17482813 |
IC50 (binding) | = 2345 nM | Inhibition of human ERbeta | ChEMBL. | 17482813 |
IC50 (binding) | = 2345 nM | Inhibition of human ERbeta | ChEMBL. | 17482813 |
Ratio IC50 (binding) | = 15 | Selectivity for human ERalpha over ERbeta | ChEMBL. | 17482813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.