Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 5 receptor | Starlite/ChEMBL | References |
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melanocortin 5 receptor | 325 aa | 311 aa | 20.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0084 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0084 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0084 | 0.5 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0084 | 0.5 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0084 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antagonist activity at human MC3R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
Activity (functional) | = 9 % | Antagonist activity at human MC3R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
Activity (functional) | = 9 % | Antagonist activity at human MC3R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
Activity (functional) | = 27 % | Antagonist activity at human MC5R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
Activity (functional) | = 27 % | Antagonist activity at human MC5R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
Activity (functional) | = 76 % | Antagonist activity at human MC4R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
Activity (functional) | = 76 % | Antagonist activity at human MC4R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
EC50 (functional) | = 21 nM | Antagonist activity at human MC4R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
EC50 (functional) | = 21 nM | Antagonist activity at human MC4R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
EC50 (functional) | = 380 nM | Antagonist activity at human MC5R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
EC50 (functional) | = 380 nM | Antagonist activity at human MC5R assessed as stimulation of cAMP production | ChEMBL. | 17768046 |
IC50 (binding) | = 3.6 nM | Binding affinity to human MC4R | ChEMBL. | 17768046 |
IC50 (binding) | = 3.6 nM | Binding affinity to human MC4R | ChEMBL. | 17768046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.