Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin B, putative | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclin b3 | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.1036 | 1 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.1036 | 1 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Schistosoma mansoni | cyclin B | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.1036 | 1 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclin b3 | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.1036 | 1 | 0.5 |
Onchocerca volvulus | 0.1036 | 1 | 0.5 | |
Schistosoma mansoni | cyclin B3 | 0.1036 | 1 | 0.5 |
Plasmodium falciparum | cyclin | 0.1036 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.1036 | 1 | 0.5 |
Schistosoma mansoni | cyclins | 0.1036 | 1 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.1036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclin B | 0.1036 | 1 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.1036 | 1 | 0.5 |
Trypanosoma cruzi | cyclin 6, putative | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.1036 | 1 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclin B3 1 | 0.1036 | 1 | 0.5 |
Leishmania major | cyclin | 0.1036 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0786 | 0 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.1036 | 1 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.1036 | 1 | 0.5 |
Trypanosoma brucei | mitotic cyclin 6 | 0.1036 | 1 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.1036 | 1 | 0.5 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.1036 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.1036 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1036 | 1 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.1036 | 1 | 0.5 |
Giardia lamblia | Cyclin A | 0.1036 | 1 | 0.5 |
Echinococcus multilocularis | cyclin B3 1 | 0.1036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1036 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 131.8 uM | Concentration giving 50% relaxation of the 30 mM KCL-induced contraction of rat aorta rings | ChEMBL. | 10780901 |
ED50 (functional) | > 300 uM | Inhibition of electrically stimulated contractions of guinea pig ileum segments. | ChEMBL. | 10780901 |
ND (functional) | 0 | Effect on Insulin secretion from rat pancreatic islets in the presence of 16.7 mM glucose at 10 uM; Not determined. | ChEMBL. | 10780901 |
RIS (functional) | = 78.7 % | Insulin secretion from rat pancreatic islets (RIS) in the presence of 16.7 mM glucose at 50 uM | ChEMBL. | 10780901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.