Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0283 | 0.0279 |
Echinococcus multilocularis | 0.4454 | 1 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0093 | 0.0089 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.4454 | 1 | 0.5 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.4454 | 1 | 0.5 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.4454 | 1 | 0.5 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.4454 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.4454 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0283 | 0.0279 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.4454 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0283 | 0.0283 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.4454 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0091 | 0.0087 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.4454 | 1 | 0.5 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.4454 | 1 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0283 | 0.0279 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0093 | 0.0089 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0004 | 0.0004 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0091 | 0.0087 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.4454 | 1 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.4454 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0093 | 0.0089 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0091 | 0.0087 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.4454 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0093 | 0.0093 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0004 | 0.0004 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.4454 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1945 | 0.4294 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0283 | 0.0279 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.4454 | 1 | 0.5 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.4454 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.1945 | 0.4294 | 0.5 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.4454 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0093 | 0.0089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.