Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Flap endonuclease-1 | 0.006 | 0.1935 | 0.1935 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0.0199 | 0.0199 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.006 | 0.1935 | 0.1935 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0043 | 0.1188 | 0.1188 |
Giardia lamblia | Flap structure-specific endonuclease | 0.006 | 0.1935 | 0.1935 |
Plasmodium vivax | flap endonuclease 1, putative | 0.006 | 0.1935 | 0.1935 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.006 | 0.1935 | 0.1935 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.006 | 0.1935 | 0.1935 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0241 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0241 | 1 | 1 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0241 | 1 | 1 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0021 | 0.0199 | 0.0199 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0043 | 0.1188 | 0.1188 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0.0199 | 0.0199 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0043 | 0.1188 | 0.1188 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.006 | 0.1935 | 0.1935 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0241 | 1 | 1 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0043 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0199 | 0.0199 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.006 | 0.1935 | 0.1935 |
Echinococcus multilocularis | 0.0241 | 1 | 1 | |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.006 | 0.1935 | 0.1935 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0021 | 0.0199 | 0.0199 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0241 | 1 | 1 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0043 | 0.1188 | 0.1188 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0199 | 0.0199 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0105 | 0.3949 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0021 | 0.0199 | 0.0199 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0035 | 0.0797 | 0.0797 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.006 | 0.1935 | 0.1935 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0199 | 0.0199 |
Mycobacterium ulcerans | hypothetical protein | 0.0105 | 0.3949 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1188 | 0.1188 |
Plasmodium falciparum | flap endonuclease 1 | 0.006 | 0.1935 | 0.1935 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0241 | 1 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0043 | 0.1188 | 0.1188 |
Schistosoma mansoni | flap endonuclease-1 | 0.0052 | 0.1585 | 0.1585 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.006 | 0.1935 | 0.1935 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.006 | 0.1935 | 0.1935 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0043 | 0.1188 | 0.1188 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0.0199 | 0.0199 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0043 | 0.1188 | 0.1188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 37.5 ug ml-1 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 75 ug ml-1 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by nitrate reductase assay | ChEMBL. | 17692520 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by nitrate reductase assay | ChEMBL. | 17692520 |
MIC (functional) | = 150 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 by broth dilution method | ChEMBL. | 17692520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.