Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0241 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0.0199 | 0.0199 |
Giardia lamblia | Flap structure-specific endonuclease | 0.006 | 0.1935 | 0.1935 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0043 | 0.1188 | 0.1188 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.006 | 0.1935 | 0.1935 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.006 | 0.1935 | 0.1935 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0021 | 0.0199 | 0.0199 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0241 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0105 | 0.3949 | 0.5 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0241 | 1 | 1 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0241 | 1 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0052 | 0.1585 | 0.1585 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0043 | 0.1188 | 0.1188 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0021 | 0.0199 | 0.0199 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0043 | 0.1188 | 0.1188 |
Mycobacterium ulcerans | hypothetical protein | 0.0105 | 0.3949 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0043 | 0.1188 | 0.1188 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.006 | 0.1935 | 0.1935 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.006 | 0.1935 | 0.1935 |
Entamoeba histolytica | Flap nuclease, putative | 0.006 | 0.1935 | 0.1935 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0021 | 0.0199 | 0.0199 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0.0199 | 0.0199 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0043 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0241 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.006 | 0.1935 | 0.1935 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0043 | 0.1188 | 0.1188 |
Echinococcus multilocularis | flap endonuclease 1 | 0.006 | 0.1935 | 0.1935 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1188 | 0.1188 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0043 | 0.1188 | 0.1188 |
Echinococcus multilocularis | 0.0241 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0199 | 0.0199 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0043 | 0.1188 | 0.1188 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0021 | 0.0199 | 0.0199 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.006 | 0.1935 | 0.1935 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0199 | 0.0199 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0021 | 0.0199 | 0.0199 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.006 | 0.1935 | 0.1935 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0241 | 1 | 1 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0035 | 0.0797 | 0.0797 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0241 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0199 | 0.0199 |
Plasmodium vivax | flap endonuclease 1, putative | 0.006 | 0.1935 | 0.1935 |
Brugia malayi | Flap endonuclease-1 | 0.006 | 0.1935 | 0.1935 |
Plasmodium falciparum | flap endonuclease 1 | 0.006 | 0.1935 | 0.1935 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0241 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 18.75 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 443 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 37.5 ug ml-1 | Antibacterial activity against Bacillus subtilis MTCC 441 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | = 75 ug ml-1 | Antibacterial activity against Staphylococcus aureus MTCC 96 by broth dilution method | ChEMBL. | 17692520 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by nitrate reductase assay | ChEMBL. | 17692520 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by nitrate reductase assay | ChEMBL. | 17692520 |
MIC (functional) | = 150 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 by broth dilution method | ChEMBL. | 17692520 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.