Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0156 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0038 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0143 | 0.8895 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0053 | 0.127 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0038 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0053 | 0.127 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0156 | 1 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0053 | 0.127 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0156 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against Staphylococcus aureus 209P JC-1 | ChEMBL. | 17889537 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa N101 | ChEMBL. | 17889537 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Escherichia coli NIH JC2 | ChEMBL. | 17889537 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against Escherichia coli NIH JC2 | ChEMBL. | 17889537 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MF490 | ChEMBL. | 17889537 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus MSC03571 | ChEMBL. | 17889537 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa PA01 | ChEMBL. | 17889537 |
MIC (functional) | > 32 ug ml-1 | Antibacterial activity against Pseudomonas aeruginosa GN315 | ChEMBL. | 17889537 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.