Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.1964 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Schistosoma mansoni | peroxidasin | 0.0074 | 0.1964 | 0.2308 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | 0.0074 | 0.1964 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0 | 0.5 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | 0.0074 | 0.1964 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | 0.0074 | 0.1964 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.8507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1964 | 1 |
Schistosoma mansoni | peroxidasin | 0.0074 | 0.1964 | 0.2308 |
Onchocerca volvulus | Peroxidasin homolog | 0.0074 | 0.1964 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.1964 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0074 | 0.1964 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.1964 | 1 |
Brugia malayi | Peroxidasin | 0.0074 | 0.1964 | 1 |
Brugia malayi | hypothetical protein | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0074 | 0.1964 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0074 | 0.1964 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0074 | 0.1964 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0074 | 0.1964 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.1964 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0074 | 0.1964 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 46 nM | Inhibition of KSP-induced nucleolin phosphorylation in cell-based mitotic arrest assay | ChEMBL. | 17766111 |
EC50 (functional) | = 46 nM | Inhibition of KSP-induced nucleolin phosphorylation in cell-based mitotic arrest assay | ChEMBL. | 17766111 |
IC50 (binding) | = 3.9 nM | Inhibition of kinesin spindle protein by ATPase assay | ChEMBL. | 17766111 |
IC50 (binding) | = 3.9 nM | Inhibition of kinesin spindle protein by ATPase assay | ChEMBL. | 17766111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.