TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 255.378 | Formula: C16H17NS
H donors: 0 H acceptors: 0 LogP: 3.48 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)[C@@H]1CN2CCC[C@H]2c2c1scc2
InChi: 1S/C16H17NS/c1-2-5-12(6-3-1)14-11-17-9-4-7-15(17)13-8-10-18-16(13)14/h1-3,5-6,8,10,14-15H,4,7,9,11H2/t14-,15-/m0/s1
InChiKey: NTPICZBSXFOFGN-GJZGRUSLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	ORL1-like opioid receptor	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	serotonin receptor	0.0101	0.0478	0.015
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0478	0.117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Echinococcus multilocularis	neuropeptides capa receptor	0.0101	0.0478	0.015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.0478	0.0083
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.0478	0.117
Brugia malayi	larval opioid receptor	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	G protein-coupled receptor	0.0101	0.0478	0.0061
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	hypothetical protein	0.0101	0.0478	0.117
Schistosoma mansoni	neuropeptide f receptor 76f	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0101	0.0478	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0146	0.1279	1
Brugia malayi	Dopamine receptor protein 2	0.0101	0.0478	0.0061
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0101	0.0478	0.015
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0101	0.0478	0.117
Brugia malayi	putative neuropeptide receptor NPR1	0.0101	0.0478	0.0061
Schistosoma mansoni	amine GPCR	0.0101	0.0478	0.117
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.0478	0.015
Echinococcus multilocularis	orexin receptor type 2	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0478	0.117
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0101	0.0478	0.0083
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0101	0.0478	0.0061
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	RE15519p	0.0101	0.0478	0.0061
Brugia malayi	neuropeptide F receptor	0.0101	0.0478	0.0061
Brugia malayi	Melatonin receptor type 1A	0.0101	0.0478	0.0061
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0146	0.1279	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Echinococcus multilocularis	serotonin receptor	0.0101	0.0478	0.015
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0146	0.1279	0.5
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0146	0.1279	0.1279
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0101	0.0478	0.015
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0146	0.1279	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0101	0.0478	0.0061
Schistosoma mansoni	amine GPCR	0.0101	0.0478	0.117
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0419	0.0419
Echinococcus multilocularis	g-protein coupled receptor	0.0101	0.0478	0.015
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Brugia malayi	hypothetical protein	0.0146	0.1279	0.0898
Loa Loa (eye worm)	TYRA-2 protein	0.0101	0.0478	0.0478
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	neuropeptide F-like receptor	0.0101	0.0478	0.117
Brugia malayi	neuropeptide F receptor	0.0101	0.0478	0.0061
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.0478	0.015
Schistosoma mansoni	opsin-like receptor	0.0101	0.0478	0.117
Echinococcus granulosus	dro:myosuppressin receptor	0.0101	0.0478	0.0083
Echinococcus granulosus	g-protein coupled receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0146	0.1279	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	sex peptide receptor	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0101	0.0478	0.117
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0101	0.0478	0.117
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0146	0.1279	0.1279
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0101	0.0478	0.0083
Echinococcus multilocularis	neuropeptide receptor	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0146	0.1279	0.5
Echinococcus granulosus	neuropeptide receptor	0.0101	0.0478	0.0083
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0101	0.0478	0.015
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0146	0.1279	0.122
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0146	0.1279	0.5
Brugia malayi	G-protein coupled receptor	0.0101	0.0478	0.0061
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0101	0.0478	0.117
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0101	0.0478	0.117
Echinococcus granulosus	serotonin receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0098	0.0419	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.0478	0.015
Brugia malayi	Dopamine receptor protein 1	0.0101	0.0478	0.0061
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0101	0.0478	0.0083
Brugia malayi	putative neuropeptide receptor	0.0101	0.0478	0.0061
Schistosoma mansoni	biogenic amine receptor	0.0101	0.0478	0.117
Brugia malayi	sulfakinin receptor protein	0.0101	0.0478	0.0061
Schistosoma mansoni	neuropeptide F-like receptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	endothelin converting enzyme 1	0.0098	0.0419	0.0067
Echinococcus granulosus	g protein coupled receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0419	0.0419
Echinococcus granulosus	neuropeptide receptor A26	0.0101	0.0478	0.0083
Echinococcus multilocularis	neuropeptide receptor	0.0101	0.0478	0.015
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0101	0.0478	0.0061
Echinococcus multilocularis	g protein coupled receptor	0.0101	0.0478	0.015
Schistosoma mansoni	biogenic amine receptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0101	0.0478	0.015
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	neuropeptides capa receptor	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	G protein-coupled receptor F59B2.13	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	Serotonin receptor	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	somatostatin receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	neuropeptides capa receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	fmrfamide receptor	0.0101	0.0478	0.015
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0101	0.0478	0.0083
Brugia malayi	Dopamine receptor	0.0101	0.0478	0.0061
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0372	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	neuropeptide Y receptor	0.0101	0.0478	0.015
Brugia malayi	AKH receptor	0.0101	0.0478	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0101	0.0478	0.0083
Schistosoma mansoni	biogenic amine receptor	0.0101	0.0478	0.117
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0419	0.0525
Echinococcus granulosus	orexin receptor type 2	0.0101	0.0478	0.0083
Echinococcus granulosus	neuropeptide Y receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0146	0.1279	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0641	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Schistosoma mansoni	amine GPCR	0.0101	0.0478	0.117
Entamoeba histolytica	aminopeptidase, putative	0.0146	0.1279	0.5
Schistosoma mansoni	opsin-like receptor	0.0101	0.0478	0.117
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	neuropeptides capa receptor	0.0101	0.0478	0.0083
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0478	0.117
Echinococcus multilocularis	G protein coupled receptor 139	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0402	0.5794	0.5794
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0101	0.0478	0.0061
Brugia malayi	Peptidase family M1 containing protein	0.0146	0.1279	0.0898
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	follicle stimulating hormone receptor	0.0101	0.0478	0.0061
Echinococcus granulosus	neuropeptide s receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0101	0.0478	0.015
Schistosoma mansoni	hypothetical protein	0.0101	0.0478	0.117
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0101	0.0478	0.015
Onchocerca volvulus		0.0146	0.1279	0.1147
Echinococcus granulosus	neuropeptide Y receptor	0.0101	0.0478	0.0083
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	neuropeptide receptor	0.0101	0.0478	0.117
Echinococcus multilocularis	somatostatin receptor	0.0101	0.0478	0.015
Mycobacterium ulcerans	aminopeptidase N PepN	0.0146	0.1279	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0372	0.0372
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0101	0.0478	0.0061
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Loa Loa (eye worm)	neuropeptide F receptor	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0101	0.0478	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.0478	0.015
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Echinococcus granulosus	allatostatin A receptor	0.0101	0.0478	0.0083
Schistosoma mansoni	adenoreceptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.0478	0.117
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0101	0.0478	0.015
Loa Loa (eye worm)	melatonin receptor type 1A	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0101	0.0478	0.0083
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0101	0.0478	0.015
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	neuropeptide Y receptor	0.0101	0.0478	0.015
Echinococcus multilocularis	allatostatin A receptor	0.0101	0.0478	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Trypanosoma cruzi	aminopeptidase, putative	0.0146	0.1279	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0101	0.0478	0.015
Echinococcus granulosus	hypothetical protein	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus multilocularis	neuropeptide s receptor	0.0101	0.0478	0.015
Schistosoma mansoni	amine GPCR	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0101	0.0478	0.117
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0146	0.1279	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0101	0.0478	0.117
Echinococcus granulosus	biogenic amine 5HT receptor	0.0101	0.0478	0.0083
Schistosoma mansoni	hypothetical protein	0.0101	0.0478	0.117
Echinococcus granulosus	tm gpcr rhodopsin	0.0101	0.0478	0.0083
Brugia malayi	GnHR receptor homolog	0.0101	0.0478	0.0061
Brugia malayi	G-protein coupled receptor	0.0101	0.0478	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0101	0.0478	0.117
Echinococcus granulosus	7tm_1 domain containing protein	0.0101	0.0478	0.0083
Mycobacterium leprae	probable zinc metalloprotease	0.0098	0.0419	0.5
Schistosoma mansoni	histamine h1 receptor	0.0101	0.0478	0.117
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Schistosoma mansoni	myosin xvIII	0.0101	0.0478	0.117
Echinococcus granulosus	sex peptide receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	aminopeptidase N	0.0497	0.7468	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Brugia malayi	Peptidase family M1 containing protein	0.0497	0.7468	0.7357
Loa Loa (eye worm)	hypothetical protein	0.0351	0.4886	0.4886
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0101	0.0478	0.117
Toxoplasma gondii	peptidase family M13 protein	0.0098	0.0419	0.5
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Echinococcus multilocularis	neuropeptide receptor A26	0.0101	0.0478	0.015
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0146	0.1279	0.122
Schistosoma mansoni	amine GPCR	0.0101	0.0478	0.117
Echinococcus granulosus	g protein coupled receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	dro:myosuppressin receptor	0.0101	0.0478	0.015
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0146	0.1279	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0101	0.0478	0.117
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0101	0.0478	0.015
Echinococcus granulosus	aminopeptidase N	0.0497	0.7468	1
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0146	0.1279	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	g protein coupled receptor	0.0101	0.0478	0.0083
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0146	0.1279	0.1279
Brugia malayi	Serotonin receptor	0.0101	0.0478	0.0061
Loa Loa (eye worm)	G-protein coupled receptor	0.0101	0.0478	0.0478
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0146	0.1279	0.122
Trypanosoma brucei	Aminopeptidase M1, putative	0.0146	0.1279	0.5
Onchocerca volvulus		0.0497	0.7468	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0101	0.0478	0.0083
Schistosoma mansoni	hypothetical protein	0.0101	0.0478	0.117
Trypanosoma brucei	Aminopeptidase M1, putative	0.0146	0.1279	0.5
Brugia malayi	hypothetical protein	0.0101	0.0478	0.0061
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0101	0.0478	0.015
Echinococcus granulosus	neuropeptide receptor	0.0101	0.0478	0.0083
Schistosoma mansoni	opsin-like receptor	0.0101	0.0478	0.117
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0101	0.0478	0.015
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0101	0.0478	0.117
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0146	0.1279	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0446	0.656	0.656
Echinococcus granulosus	neuropeptide FF receptor 2	0.0101	0.0478	0.0083
Echinococcus multilocularis	fmrfamide receptor	0.0101	0.0478	0.015
Echinococcus granulosus	biogenic amine 5HT receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	G-protein coupled receptor	0.0101	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0101	0.0478	0.0478
Echinococcus granulosus	G protein coupled receptor 139	0.0101	0.0478	0.0083
Echinococcus granulosus	fmrfamide receptor	0.0101	0.0478	0.0083
Loa Loa (eye worm)	aminopeptidase N	0.0146	0.1279	0.1279
Schistosoma mansoni	growth hormone secretagogue receptor	0.0101	0.0478	0.117
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	neuropeptide F receptor	0.0101	0.0478	0.0478
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0101	0.0478	0.117
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0419	0.0419
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0101	0.0478	0.0478
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0146	0.1279	0.122
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0101	0.0478	0.015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0101	0.0478	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0478	0.0478

Activities

Activity type	Activity value	Assay description	Source	Reference
behavior (functional)	D 0	Gross behavioral effects ascertained in mice; D indicates significant depressant properties.	ChEMBL.	3039136
ED50 (functional)	I-30 0 mg kg-1	Ability to antagonise intraperitoneal dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30.	ChEMBL.	3039136
ED50 (functional)	I-30 0 mg kg-1	Ability to antagonise tetrabenazine(TBZ)-induced depression measured in mice for ptosis by 10 mg/kg i.p. dose; inactive (<10% antagonism) at 30 mgjkg is represented as I-30.	ChEMBL.	3039136
Inhibition (functional)	= 10 %	Ability to inhibit the uptake of tritiated dopamine (DA) at 0.1 mg/kg concentration	ChEMBL.	3039136
Inhibition (functional)	= 28 %	Ability to inhibit the uptake of tritiated serotonin(5-HT) at 0.1 mg/kg concentration	ChEMBL.	3039136
Inhibition (functional)	= 34 %	Ability to inhibit the uptake of tritiated norepinephrine(NE) at 0.1 mg/kg concentration	ChEMBL.	3039136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 46056