Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Brugia malayi | bZIP transcription factor family protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus multilocularis | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1276 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.1276 | 0.5 |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.8724 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0101 | 1 | 0.5 |
Echinococcus granulosus | jun protein | 0.0101 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antitumor activity against HepG2 cells xenografted nude mouse at 9 mg/kg, ip twice per day on every third day for four cycles | ChEMBL. | 17531481 |
Activity (functional) | 0 | Down regulation of cyclin D1 expression in HepG2 cells | ChEMBL. | 17531481 |
GI50 (functional) | = 11 nM | Cytotoxicity against PANC1 cells | ChEMBL. | 17531481 |
GI50 (functional) | = 11 nM | Cytotoxicity against PANC1 cells | ChEMBL. | 17531481 |
GI50 (functional) | = 13 nM | Cytotoxicity against HepG2 cells | ChEMBL. | 17531481 |
GI50 (functional) | = 13 nM | Cytotoxicity against HepG2 cells | ChEMBL. | 17531481 |
IC50 (binding) | = 11 nM | Inhibition of NFkappaB-mediated gene transcription in HepG2 cells by luciferase reporter gene assay | ChEMBL. | 17531481 |
IC50 (binding) | = 68 nM | Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay | ChEMBL. | 17531481 |
IC50 (binding) | = 68 nM | Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assay | ChEMBL. | 17531481 |
IC50 (binding) | = 135 nM | Inhibition of CRE-mediated gene transcription in HepG2 cells by luciferase reporter gene assay | ChEMBL. | 17531481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.