Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.6802 | 0.6802 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6802 | 0.6802 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6802 | 0.6802 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6802 | 0.6802 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6802 | 0.6802 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6802 | 0.6802 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6802 | 0.6802 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.6802 | 0.6802 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0064 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6802 | 0.6802 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Agonist activity at human CB2 receptor by GTPgamma[35S] assay | ChEMBL. | 17884494 | |
EC50 (functional) | 0 | Agonist activity at human CB2 receptor by GTPgamma[35S] assay | ChEMBL. | 17884494 |
Ki (binding) | = 27.8 nM | Binding affinity to human CB2 receptor | ChEMBL. | 17884494 |
Ki (binding) | = 27.8 nM | Binding affinity to human CB2 receptor | ChEMBL. | 17884494 |
Ki (binding) | = 973 nM | Binding affinity to human CB1 receptor | ChEMBL. | 17884494 |
Ki (binding) | = 973 nM | Binding affinity to human CB1 receptor | ChEMBL. | 17884494 |
Ratio Ki (binding) | = 35 | Selectivity for human CB2 receptor over human CB1 receptor | ChEMBL. | 17884494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.