Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0899 | 0.6376 | 0.6376 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0097 | 0.0485 | 0.3121 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0119 | 0.0891 |
Giardia lamblia | Kinase, PLK | 0.0097 | 0.0485 | 0.5 |
Onchocerca volvulus | 0.0242 | 0.1554 | 1 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0119 | 0.0891 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0097 | 0.0485 | 0.0485 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.0485 | 0.0485 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0097 | 0.0485 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1393 | 1 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.0899 | 0.6376 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0097 | 0.0485 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0484 | 0.3327 | 0.3327 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1048 | 0.1048 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.1338 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0119 | 0.0119 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.0485 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1048 | 0.1048 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0119 | 0.0119 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.1338 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0097 | 0.0485 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0899 | 0.6376 | 0.6376 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0484 | 0.3327 | 0.3327 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0097 | 0.0485 | 0.3624 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0899 | 0.6376 | 0.6376 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | kinase | 0.0049 | 0.0136 | 0.0136 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0097 | 0.0485 | 0.3624 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0899 | 0.6376 | 0.6376 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.0485 | 0.2509 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0097 | 0.0485 | 0.0485 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1048 | 0.1048 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0484 | 0.3327 | 0.3327 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.1554 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1393 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0119 | 0.0119 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0119 | 0.0119 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.0485 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0119 | 0.0119 |
Echinococcus granulosus | geminin | 0.0173 | 0.1048 | 0.1048 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0119 | 0.0119 |
Echinococcus granulosus | neuropeptide s receptor | 0.0484 | 0.3327 | 0.3327 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 102.22 uM | Cytotoxicity against human OV3 cells by SRB assay | ChEMBL. | 17827007 |
IC50 (functional) | = 155.3 uM | Cytotoxicity against human A549 cells by SRB assay | ChEMBL. | 17827007 |
IC50 (functional) | = 155.3 uM | Cytotoxicity against human A549 cells by SRB assay | ChEMBL. | 17827007 |
IC50 (functional) | = 157.54 uM | Cytotoxicity against human SK-MEL-2 cells by SRB assay | ChEMBL. | 17827007 |
IC50 (functional) | = 157.54 uM | Cytotoxicity against human SK-MEL-2 cells by SRB assay | ChEMBL. | 17827007 |
IC50 (functional) | = 171.36 uM | Cytotoxicity against human HCT15 cells by SRB assay | ChEMBL. | 17827007 |
IC50 (functional) | = 171.36 uM | Cytotoxicity against human HCT15 cells by SRB assay | ChEMBL. | 17827007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.