Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Antiinflammatory activity in neutophils assessed as inhibition of oxygen radical generation | ChEMBL. | 17197180 |
IC50 (functional) | > 40 uM | Antiinflammatory activity in neutorphil assessed as inhibition of fMLP induced elastase release | ChEMBL. | 17197180 |
IC50 (functional) | > 100 uM | Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation | ChEMBL. | 17197180 |
IC50 (functional) | > 100 uM | Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation | ChEMBL. | 17197180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.