Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0086 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.5 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0086 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0086 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0086 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0086 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0086 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0086 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0086 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0086 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0086 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0086 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0086 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Antiinflammatory activity in neutophils assessed as inhibition of oxygen radical generation | ChEMBL. | 17197180 |
IC50 (functional) | > 40 uM | Antiinflammatory activity in neutorphil assessed as inhibition of fMLP induced elastase release | ChEMBL. | 17197180 |
IC50 (functional) | = 80.8 uM | Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation | ChEMBL. | 17197180 |
IC50 (functional) | > 100 uM | Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation | ChEMBL. | 17197180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.