Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.9544 | 0.9544 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0191 | 0.9544 | 0.9144 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0227 | 0.0227 |
Brugia malayi | Carboxylesterase family protein | 0.0198 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0198 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0198 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0198 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.9544 | 0.9144 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0198 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.3 mM | Inhibition of rabbit glycogen phosphorylase B enzyme | ChEMBL. | 9154968 |
Log Ki (binding) | = 2.886 | Affinity of the compound was determined on glycogen phosphorylase(GP) enzyme. | ChEMBL. | 9435905 |
Log Ki (binding) | = 2.89 mM | Inhibitory activity against rabbit muscle glycogen phosphorylase | ChEMBL. | 9406599 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.