Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase II | 0.4682 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4682 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4682 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4682 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1446 | 0.0349 | 0.0349 |
Brugia malayi | Protein kinase domain containing protein | 0.45 | 0.9455 | 0.9455 |
Loa Loa (eye worm) | hypothetical protein | 0.3388 | 0.6141 | 0.6141 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4682 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Onchocerca volvulus | 0.1448 | 0.0356 | 0.0016 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.3388 | 0.6141 | 0.6141 |
Onchocerca volvulus | 0.1446 | 0.0349 | 0.0003 | |
Loa Loa (eye worm) | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Echinococcus granulosus | carbonic anhydrase II | 0.4682 | 1 | 1 |
Brugia malayi | LBP/BPI | 0.1446 | 0.0349 | 0.0349 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.1942 | 0.183 | 0.183 |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Brugia malayi | hypothetical protein | 0.1446 | 0.0349 | 0.0349 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.3388 | 0.6141 | 0.6141 |
Leishmania major | carbonic anhydrase-like protein | 0.4682 | 1 | 0.5 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.1942 | 0.183 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4682 | 1 | 1 |
Onchocerca volvulus | 0.1942 | 0.183 | 0.2558 | |
Echinococcus multilocularis | rho associated protein kinase | 0.1448 | 0.0356 | 0.0356 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.1448 | 0.0356 | 0.0356 |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.3388 | 0.6141 | 0.6141 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4682 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.1942 | 0.183 | 0.183 |
Brugia malayi | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Plasmodium falciparum | carbonic anhydrase | 0.1329 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.1446 | 0.0349 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4682 | 1 | 0.5 |
Onchocerca volvulus | 0.1942 | 0.183 | 0.2558 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.1448 | 0.0356 | 0.0356 |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4682 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1942 | 0.183 | 0.183 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.3388 | 0.6141 | 0.6141 |
Loa Loa (eye worm) | hypothetical protein | 0.1446 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.1446 | 0.0349 | 0.0349 |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Onchocerca volvulus | 0.3388 | 0.6141 | 1 | |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.45 | 0.9455 | 0.9455 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.1942 | 0.183 | 0.183 |
Toxoplasma gondii | hypothetical protein | 0.1329 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1446 | 0.0349 | 0.0349 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.1942 | 0.183 | 0.183 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6420 nM | Functional activity against adenosine A2a receptor from rat aorta. | ChEMBL. | 7739005 |
EC50 (functional) | > 10 uM | Functional activity against adenosine A1 receptor from rat atria. | ChEMBL. | 7739005 |
k' (ADMET) | = 0.32 | Hydrophobicity index (k'') (RP-HPLC pH 7.5) | ChEMBL. | 7739005 |
Ki (binding) | = 1500 nM | Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand. | ChEMBL. | 7739005 |
Ki (binding) | = 7498 nM | Binding affinity against adenosine A1 receptor from rat brain using [3H]-CHA as a radioligand. | ChEMBL. | 7739005 |
Potency ratio (functional) | = 0.003 | Anti-aggregatory activity against adenosine A2A receptor from rabbit platelets. Potency ratio was reported with reference to the NECA IC50 of 0.2 uM. | ChEMBL. | 7739005 |
Selectivity (binding) | = 5 | Selectivity as the ratio of Ki value towards A1 receptor to that of A2a receptor. | ChEMBL. | 7739005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.