Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1491 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1491 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0135 | 0.5211 | 0.7728 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1618 | 0.2399 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1491 | 0.2211 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1491 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.6743 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.1618 | 0.1879 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 0.5211 | 0.7728 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 0.5211 | 0.7728 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.1618 | 0.2399 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.5211 | 0.6051 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0167 | 0.6743 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1618 | 0.2399 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.1618 | 0.1879 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.2211 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.1618 | 0.1879 |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 0.5211 | 0.6051 |
Echinococcus multilocularis | geminin | 0.0167 | 0.6743 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 0.5211 | 0.7728 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.1618 | 0.1879 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.5211 | 0.6051 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 0.5211 | 0.7728 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1618 | 0.2399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1618 | 0.2399 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.5211 | 0.6051 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.2211 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0135 | 0.5211 | 0.6051 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1491 | 0.2211 |
Brugia malayi | RNA binding protein | 0.0062 | 0.1618 | 0.1879 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.1618 | 0.2399 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.8611 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.1618 | 0.1879 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0135 | 0.5211 | 0.7728 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.8611 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 0.5211 | 0.7728 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.5211 | 0.6051 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1491 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.6743 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1618 | 0.2399 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | mg kg-1 | Analgesic activity against acetic acid induced writhing test in mouse administered peroral dose of 25 mg/kg; IA=Inactive | ChEMBL. | 3133478 |
ED50 (functional) | 0 mg kg-1 | Analgesic activity against acetic acid induced writhing test in mouse administered peroral dose of 25 mg/kg; IA=Inactive | ChEMBL. | 3133478 |
ED50 (functional) | 0 mg kg-1 | Antiinflammatory activity against carrageenin-induced foot edema in rat after oral administration of 25 mg/kg; IA=Inactive | ChEMBL. | 3133478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.