Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.828 | 0 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.839 | 1 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.839 | 1 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 0.839 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.828 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.12 ug ml-1 | In vitro minimal inhibitory concentration against Morganella morganii CMC-84-39(Mn) | ChEMBL. | 2104934 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimal inhibitory concentration against Escherichia coli ATCC 25922 (Ec(A)) | ChEMBL. | 2104934 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimal inhibitory concentration against Enterobacter cloacae VGH-84-39 (Et(c)) | ChEMBL. | 2104934 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimal inhibitory concentration against Escherichia coli ATCC 25922 (Ec(A)) | ChEMBL. | 2104934 |
MIC (functional) | = 0.5 ug ml-1 | In vitro minimal inhibitory concentration against Escherichia coli #311 (Ec(B)) | ChEMBL. | 2104934 |
MIC (functional) | = 0.5 ug ml-1 | In vitro minimal inhibitory concentration against Escherichia coli #311 (Ec(B)) | ChEMBL. | 2104934 |
MIC (functional) | = 2 ug ml-1 | In vitro minimal inhibitory concentration against Pseudomonoas aeruginosa 12-4-4 (Pa) | ChEMBL. | 2104934 |
MIC (functional) | = 4 ug ml-1 | In vitro minimal inhibitory concentration against Staphylococcus aureus Smith (MP) (Sa(A)) | ChEMBL. | 2104934 |
MIC (functional) | = 16 ug ml-1 | In vitro minimal inhibitory concentration against Staphylococcus aureus ATCC 29213 (Sa(B)) | ChEMBL. | 2104934 |
MIC (functional) | = 16 ug ml-1 | In vitro minimal inhibitory concentration Streptococcus faecalis VGH-84 (Sf(V)) | ChEMBL. | 2104934 |
MIC (functional) | = 16 ug ml-1 | In vitro minimal inhibitory concentration against Streptococcus faecalis UCI-85 (Sf(U)) | ChEMBL. | 2104934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.