Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0309 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.008 | 0 | 0.5 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0305 | 0.9816 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0305 | 0.9816 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.008 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.008 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.008 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.008 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.008 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.008 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.008 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0309 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.008 | 0 | 0.5 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0207 | 0.5523 | 0.4101 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0305 | 0.9816 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.4 uM | Inhibitory constant for human neutrophil elastase | ChEMBL. | 10360758 |
Ki (binding) | = 791 uM | Inhibitory constant for porcine pancreatic elastase | ChEMBL. | 10360758 |
Koff (binding) | = 0.001835 s-1 | Kinetic constant of the compound for human neutrophil elastase | ChEMBL. | 10360758 |
Kon (binding) | = 339.3 M-1 s-1 | Kinetic constant of the compound for human neutrophil elastase | ChEMBL. | 10360758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.