Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0127 | 1 | 1 |
Leishmania major | tyrosyl or methionyl-tRNA synthetase-like protein | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma brucei | trypanothione reductase | 0.0127 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Plasmodium vivax | methionine-tRNA ligase, putative | 0.0049 | 0.0609 | 0.0609 |
Toxoplasma gondii | thioredoxin reductase | 0.0127 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 0.233 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0127 | 1 | 1 |
Toxoplasma gondii | tRNA synthetases class I family protein | 0.0063 | 0.233 | 0.233 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit beta | 0.0049 | 0.0609 | 1 |
Trichomonas vaginalis | methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.2615 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.0609 |
Brugia malayi | Thioredoxin reductase | 0.0127 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0609 | 0.0609 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0127 | 1 | 1 |
Echinococcus multilocularis | aminoacyl tRNA synthase complex interacting | 0.0049 | 0.0609 | 0.0609 |
Plasmodium vivax | glutathione reductase, putative | 0.0127 | 1 | 1 |
Plasmodium falciparum | tyrosine--tRNA ligase | 0.0063 | 0.233 | 0.233 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0127 | 1 | 1 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, beta chain PheT | 0.0049 | 0.0609 | 0.0609 |
Toxoplasma gondii | tRNA binding domain-containing protein | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma brucei | tyrosyl/methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0049 | 0.0609 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0127 | 1 | 1 |
Echinococcus granulosus | tyrosyl tRNA synthetase | 0.0112 | 0.8243 | 0.8243 |
Leishmania major | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 0.233 |
Schistosoma mansoni | tyrosyl-tRNA synthetase | 0.0112 | 0.8243 | 0.8243 |
Schistosoma mansoni | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.0609 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 1 |
Trichomonas vaginalis | isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative | 0.0063 | 0.233 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0049 | 0.0609 | 0.0609 |
Echinococcus granulosus | aminoacyl tRNA synthase complex interacting | 0.0049 | 0.0609 | 0.0609 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0609 | 0.2615 |
Brugia malayi | methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.0609 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0049 | 0.0609 | 0.2615 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit beta | 0.0049 | 0.0609 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0127 | 1 | 1 |
Entamoeba histolytica | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0127 | 1 | 1 |
Plasmodium falciparum | tRNA import protein tRIP | 0.0049 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0127 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0127 | 1 | 1 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Plasmodium vivax | tyrosine--tRNA ligase, putative | 0.0063 | 0.233 | 0.233 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0063 | 0.233 | 0.233 |
Giardia lamblia | Tyrosyl-tRNA synthetase | 0.0063 | 0.233 | 1 |
Leishmania major | hypothetical protein | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0049 | 0.0609 | 0.0609 |
Echinococcus multilocularis | tyrosyl tRNA synthetase | 0.0112 | 0.8243 | 0.8243 |
Loa Loa (eye worm) | glutathione reductase | 0.0127 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1 uM | Antioxidant activity in bovine heart mitochondria using iron(II) / dihydroxy fumaric acid (DHF) | ChEMBL. | 8496914 |
IC50 (binding) | = 11 uM | Inhibition against peroxidation of liposomal suspension of dilinoleoylphosphatidylcholine (DPLC) intiated by DMVN at 40 degree centigrade | ChEMBL. | 8496914 |
Inhibition (binding) | = 13 % | Percent inhibition at 100 microM against peroxidation of methyl linoleate / DMVN in TBA /methanol medium at 40 degree centigrade | ChEMBL. | 8496914 |
RC10 (functional) | = 6.2 uM | Reducing activity to scavenge 10 uM 1, 1-diphenylpicrylhydrazyl (DPPH) | ChEMBL. | 8496914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.