Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus subsp. aureus Mu50 | Peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein | Peptide deformylase | 183 aa | 155 aa | 22.6 % |
Trichomonas vaginalis | abca6, putative | Peptide deformylase | 183 aa | 162 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.0664 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 1 | 0.5 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0242 | 0.7984 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0242 | 0.7984 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0109 | 0.0808 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0242 | 0.7984 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0109 | 0.0808 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0109 | 0.0808 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0109 | 0.0808 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.0664 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.0664 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0109 | 0.0808 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0242 | 0.7984 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.0664 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0109 | 0.0808 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0242 | 0.7984 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.0664 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.0664 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.0664 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.