Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 1 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.013 | 0.4863 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.8618 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0052 | 0.1102 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.013 | 0.4863 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0116 | 0.4208 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.013 | 0.4863 | 0.6276 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0189 | 0.7718 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0053 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0189 | 0.7718 | 0.8949 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.4863 | 0.5616 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0052 | 0.1102 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.013 | 0.4863 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0053 | 0.0109 |
Toxoplasma gondii | prolyl endopeptidase | 0.013 | 0.4863 | 1 |
Onchocerca volvulus | 0.0173 | 0.6909 | 0.6892 | |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.013 | 0.4863 | 0.4836 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0189 | 0.7718 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.013 | 0.4863 | 0.5616 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.013 | 0.4863 | 0.6276 |
Trypanosoma brucei | prolyl endopeptidase | 0.013 | 0.4863 | 1 |
Onchocerca volvulus | 0.0189 | 0.7718 | 0.7706 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.8618 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.013 | 0.4863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.7718 | 0.8949 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.7718 | 0.8949 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | ND 0 % | Antiallergic activity against passive cutaneous anaphylaxis(PCA) in male Sprague-Dawley rats after 0.3 mg/kg oral administration;ND means no data. | ChEMBL. | 6137568 |
Inhibition (functional) | ND 0 % | Antiallergic activity against passive cutaneous anaphylaxis (PCA) in male Sprague-Dawley rats (10 mg/kg oral administration) | ChEMBL. | 6137568 |
Inhibition (functional) | = 21 % | Inhibition of passive cutaneous anaphylaxis in male Sprague-Dawley rats following 1 mg/kg p.o. administration; Not significant. | ChEMBL. | 6137568 |
Inhibition (functional) | = 82 % | Antiallergic activity against passive cutaneous anaphylaxis(PCA) in male Sprague-Dawley rats after 3.0 mg/kg oral administration | ChEMBL. | 6137568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.