Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0461 | 0.2662 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0421 | 0.223 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.2662 | 1 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0461 | 0.2662 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0469 | 0.2743 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.223 | 0.8377 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.2662 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1139 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0421 | 0.223 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0421 | 0.223 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 mM | Inhibitory concentration of the compound against E. coli Pyrophosphate Synthetase (PRPP) | ChEMBL. | No reference |
IC50 (binding) | = 1 mM | Inhibitory concentration of the compound against E. coli Pyrophosphate Synthetase (PRPP) | ChEMBL. | No reference |
Km (binding) | mM | Km value of the compound as a substrate for Pyrophosphate Synthetase (PRPP); ND=Not determined | ChEMBL. | No reference |
Km (binding) | 0 mM | Km value of the compound as a substrate for Pyrophosphate Synthetase (PRPP); ND=Not determined | ChEMBL. | No reference |
Vmax (binding) | = 0.07 % | Vmax of the compound as a substrate for Pyrophosphate Synthetase (PRPP) | ChEMBL. | No reference |
Vmax (binding) | = 0.07 % | Vmax of the compound as a substrate for Pyrophosphate Synthetase (PRPP) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.